The opioid crisis has become a major global health problem, deeply affecting individuals, families, and communities. Every year, about 310 million major surgeries are performed worldwide, including 50 million in the United States, 20 million in Europe, and 6 million in the United Kingdom. For decades, opioids have been the go-to treatment for managing pain after surgery. While they are effective in relieving pain, long-term use can lead to addiction and dependency. This misuse has contributed to rising healthcare costs and a concerning increase in overdose deaths. For most patients, opioids are first introduced during surgery, either as part of anesthesia or for short-term pain relief, and they are typically stopped without issue. However, some individuals end up in a pattern of "persistent opioid use," which means they continue using opioids for more than three months after surgery. Identifying these at-risk patients is crucial for preventing dependency and addressing the opioid crisis. By recognizing which patients are more vulnerable to long-term opioid use, doctors can take steps to reduce risks. This includes educating patients about the dangers of opioids and offering alternative ways to manage pain without relying on these medications.